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Given that free cuprous ions catalyse hydroxyl radical formation via the Fenton and HarberWeiss reactions [13, 17], hydrogen peroxide levels were measured in copper-treated cells

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In the papers discussion, the authors wrote: Chronoferroptosis could explain the prolonged prodromal period between initial iron accumulation and GSH depletion and eventual neuronal loss in neurodegenerative diseases, thereby defining a critical therapeutic window for early intervention before cells transition to irreversible degeneration. There may be a long stretch of time before neurons die when they are still reachable

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The Journal of Dermatology, 44 (4), 449454

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