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Interestingly, isolated respiring rat brain mitochondria increased ROS production when their medium was alkalinized [100]

Sato K, Asai TT, Jimi S

Oxidative stress plays a significant role in Parkinsons disease, marked by the accumulation of free radicals, lipid peroxidation, and impaired mitochondrial function

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Skin has a saturation point

10.1016/j.bbagen.2006.02.020 66 SinningI.KleywegtG
