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Wang W, Bai M, Jiang T, Li C, Li P, Zhou H, et al

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Short-term supplementation increased fat oxidation and improved 40 km time-trial performance in recreational cyclists [44], while acute high-dose supplementation enhanced time-to-exhaustion and reduced CK and MDA in young adults [60]

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Because metabolic remodeling is a hallmark of HF (Ingwall, 2009) and atrial fibrillation (Harada et al., 2017) it is pertinent to determine if insulin resistance and diabetes alters how LCACs are handled in these hearts and whether this cardio-metabolic interaction drives disease phenotype

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