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The two main drugs include apraclonidine and brimonidine, with the latter more widely used due to improved tolerability and a more favorable side-effect profile

An acceptable safety and tolerability profile was also observed in phase 1/2 studies

This concept, proposed in the Azalea Hypothesis by Steve LeVine [43] , suggests that despite appearing iron overloaded, cells may be unable to access usable iron for mitochondrial processes (Figure 2)

[DOI] [PubMed] [Google Scholar] 67.Leeming E.R., Louca P., Gibson R., Menni C., Spector T.D., Le Roy C.I

The effect is small but the convention is to keep them upright

Griffiths, B