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Three parameters mainly determine the specific and effective Cre-loxP recombination in vivo : (1) the dose and duration of TAM that determine the activity of the potent metabolites 4-OH-TAM and END, (2) the level of Cre ERT2 expression and (3) the chromatin structure and epigenetic status of the floxed alleles

K., Goldstein, A

Salmeterol Efficacy and Bias in the Activation and Kinase-Mediated Desensitization of beta2-Adrenergic Receptors

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References Lau, D., Erichsen, L., Francisco, A., Satylganova, A., Roux, C., McGowan, B., Pedersen, S., Pietilinen, K., Rubino, D., & Batterham, R

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