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After each increase, blood levels peak over 24 to 72 hours, when nausea and fullness are most likely to return

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Rather than focusing on a single physiological pathway, it has become relevant to investigations spanning enzymology, cellular metabolism and molecular signalling

This search often leads athletes and coaches down paths of complex nutritional science, advanced training modalities, and sometimes, into the gray area of performance-enhancing substances

Contraindications include pregnancy or breastfeeding, active or suspected cancer, and severe liver or kidney disease