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In further embodiments, the invention encompasses a method of modulating stem cell differentiation by contacting a stem cell expressing NNMT with one or more cations chosen from Tables 1, 2, 3a, and 3b

Real-world data from clinics offering this combination protocol suggests enhanced fat loss compared to tirzepatide alone, but these observations come from uncontrolled clinical settings and cannot substitute for randomized controlled trials

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However, normal-weight mice did not experience fat loss, suggesting the effect may depend on existing metabolic dysfunction

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