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Phase (approx.) Cagrilintide dose Frequency Weeks 14 0.25 mg Once weekly Weeks 58 0.5 mg Once weekly Weeks 912 1.0 mg Once weekly Weeks 1316 1.7 mg Once weekly Week 17 onward 2.4 mg (max studied) Once weekly This step-wise schedule mirrors the titration used in cagrilintide and CagriSema studies ( Lau et al., Lancet 2021

Many studies were small, used different dosing methods, and do not provide the kind of large-scale evidence used to support standard insomnia treatments

CeA neurons can be characterized as Type A or B based on the absence or presence of spike accommodation in response to prolonged depolarization current