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TSP also attenuated CP-induced oxidative stress by increasing the Nrf2/HO-1 signaling pathway and increasing the levels of kelch-like ECH-associated protein 1 (Keap1), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and malondialdehyde (MDA)

Regulating lipid peroxidation may become an important strategy for the future treatment of sarcopenia

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Since elevated glutamate levels are linked to relapse, study authors were encouraged by the findings

Our identification of VRK2-mediated SLC7A11 trafficking suggests a potential immune evasion mechanism, as SLC7A11-high tumors often display T cell exclusion phenotypes [37], warranting future investigation into whether VRK2 expression could predict therapeutic response to combined ferroptosis inducers and immune checkpoint inhibitors

References Trookman, N