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Common gastrointestinal side effects include: Nausea the most frequently reported side effect, particularly during dose escalation Vomiting often linked to nausea and typically dose-dependent Diarrhoea and constipation both have been reported, reflecting altered gut motility Decreased appetite a desired therapeutic effect, but one that requires monitoring to ensure adequate nutrition Severe or prolonged vomiting and diarrhoea can lead to dehydration and, in some cases, acute kidney injury (AKI)

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Animals and Surgery Male (n=33) and female (n=19) Long-Evans rats were single-housed with enrichment on a 12/12-hour reverse light cycle and maintained at 85100% free-feeding weight (5% bodyweight of chow/day)