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Endoplasmic reticulum stress (ERS) dynamically regulates cell fate decisions within the tumor microenvironment (TME) through the PERK, IRE1, and ATF6 pathways of the unfolded protein response (UPR), forming an ERS-Death Axis interconnected with apoptosis, autophagy, pyroptosis, and ferroptosis

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This decline is of particular concern because lower levels of glutathione are associated with several age-related health issues