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In contrast, studies in which the participants had adequate vitamin C status at baseline (means approximately 50 mol/L) had much smaller differences between the nonliposomal and liposomal AUCs (e.g., 1.3 to 1.4fold) [21, 25, 26], None of the studies reported ascorbate elimination over the sampling period

Ruby et al., 2018

However, since the number of patients in the study (43,555) is less than the RIS (65,384), the study does not have sufficient statistical power

In the following years, many studies seemed to support this hypothesis

Comparison of the Effects of L-Carnitine and Acetyl-L-Carnitine on Carnitine Levels, Ambulatory Activity, and Oxidative Stress Biomarkers in the Brain of Old Rats