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Acknowledgements This work was supported by National Natural Science Foundation Grants (No: 32070117 and 32200080) and Gansu provincial talent project (No: GSPTP-2024-2)

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It is designed to be inserted into the rectum where it dissolves or melts, releasing the glutathione for local absorption or to be carried into the systemic circulation

Second, activation of the nuclear factor kappa B (NFB)-mediated pathway causes an increase in the expression of cytokines belonging to the IL-1 family that in turn promote the release of a cascade of inflammatory cytokines such as TNF- and IL-6 (Rolle et al., 2021)

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Giralt S, Thall PF, Khouri I, Wang X, Braunschweig I, Ippolitti C, Claxton D, Donato M, Bruton J, Cohen A, Davis M, Andersson BS, Anderlini P, Gajewski J, Kornblau S, Andreeff M , Przepiorka D, Ueno NT, Molldrem J, Champlin R
