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Effector Treg cells take up lactate through MCT1 to enhance PD-1 expression and remodel its function and phenotype, which may be one of the reasons for resistance to PD-1 immunotherapy [16]

doi:10.1016/j.annder.2012.10.597

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doi: 10.7554/eLife.78565

Consequently, the study was ultimately terminated (de Bruyn et al., 2021)

Here, we report that ALC reduced SREBP2 and HMGCR expression in mouse livers and human hepatoma cells and increased the expression of cholesterol metabolism-related genes, such as Ldlr , in the livers of ALC-fed mice