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10.1097/TP.0b013e31820ae459 40 GustafsonE.AsifS.KozarcaninH.ElgueG.MeurlingS.EkdahlK

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In addition, the nanoscale activator based on Mn-quercetin coordination synthesized by mixing manganese tetrachloride tetrahydrate (MnCl 2 4H 2 O) with an ethanol solution of quercetin, releases manganese ions that promote the generation of ROS, and enhances photothermal-induced DNA damage when combined with quercetin-induced apoptosis and further promotes the release of cytoplasmic DNA thereby activating the cGAS-STING pathway, enhancing immune activation and effectively inhibiting tumor growth (234)