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[Effect of competitive antagonist of transmembrane glutamine flux V-9302 on apoptosis of acute myeloid leukemia cell lines HL-60 and KG-1]

To address the limited tumor uptake, nanoparticles can be designed to actively target tumor tissue-specific overexpressed proteins using a combination of active and passive targeting strategies, facilitating receptor-mediated endocytosis

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It enhances the activity of immune cells like T cells and NK cells, promote immune tolerance through the regulation of Tregs, and reduces the accumulation of MDSCs while up-regulating critical immune genes

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These effects contribute to reduced inflammation and oxidative damage in chronic conditions