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Montoyo, H

Side effects to watch for at any dose step All FDA-approved GLP-1 receptor agonists and GIP/GLP-1 dual agonists carry the class boxed warning for thyroid C-cell tumor risk observed in rodent studies

The hPrdx6 (1 mg/ml) at pH 7.0 and pH 4.0 was subjected to SEC, equilibrated with 3 bed volumes of 10 mM TrisHCl buffer (pH 7.0), and 10 mM sodium acetate buffer (pH 4.0), respectively

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It targets the follicle microenvironment rather than the hormonal trigger

Eluted proteins were concentrated using Amicon Ultra centrifugal filters (10 kDa or 30 kDa MWCO) and further purified by size-exclusion chromatography on a HiLoad 16/600 Superdex 200 prep-grade column (Cytiva) equilibrated with 20 mM HEPES (pH 7.5) and 150 mM NaCl