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On the other hand, severe reactions such as anaphylactic shock can occur, albeit only in rare cases

They are capable of transforming the chromatin structure, either facilitating or impeding the access of transcription factors to their target genes, thus enabling a precise regulation of gene activity

10.1007/s00586-008-0822-7 184 MouwJ

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40,41 Meanwhile, excess androgens encourage insulin resistance, leading to dysfunctional signaling by fat tissue and further elevated insulin levels, which in turn stimulate weight gain and androgen synthesis

Multiple sessions are required, and improvement is gradual, becoming most visible at the three-month mark and continuing to develop for up to a year after the final session