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You would never know by looking at it, because the solution might still appear clear, but the biological activity would be degraded

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[DOI] [PubMed] [Google Scholar] 225.Chen F., Marquez H., Kim Y.-K., Qian J., Shao F., Fine A., Cruikshank W.W., Quadro L., Cardoso W.V

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There are numerous methods for enhancing DNA vaccine immunogenicity