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then in the above-mentioned resin, add DIEA, DIC or DMAP, Fmoc-Val-OH, react at 10-50C for 0.5-5 hours, then add blocking reagent methanol, benzoyl chloride or pyridine and react at 10-50C for 0.2-3 hours, resin with isopropanol, N,N-di Methylformamide washes to obtain Fmoc-Val-resin

The FDA also recommends examining hard clinical endpoints such hepatic decompensations, transplant free survival, and all-cause mortality, although these results are not necessarily needed prior to drug approval given the long length of follow up potentially required

If you do that, it should be guided and monitored
