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[DOI] [PMC free article] [PubMed] [Google Scholar] 6.Mller TD, Finan B, Bloom SR, et al

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However, observational studies suggest that whilst acute toxicity remains exceptionally rare, sustained very high levels of B12particularly from supplements or injectionsmay be associated with certain health concerns, though these are correlations rather than proven causal relationships

Interleukin-1 Interleukin-1 (IL-1) is markedly elevated in intestinal mucosa under inflammatory conditions, such as CD patients.44 In clinical studies, an IL-1 receptor antagonist is currently being developed for therapeutic usage, which indicates IL-1 plays a central role in the intestinal inflammatory process.45 Furthermore, recent studies show that IL-1 causes increased intestinal TJ permeability