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L-Thyroxine (T 4 ), the prohormone exclusively secreted by the thyroid gland, ranks among the top five drugs prescribed by physicians [1] ( accessed on 6 February 2023)

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Subsequent studies in rats have shown that subcutaneous administration of recombinant IGF-1 may be associated with exacerbation of the ischemic renal damage through stimulation of neutrophil infiltration and inflammation.38 This mechanism could be related to the unfavorable results in patients with acute renal failure

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