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Preclinical Studies Early preclinical studies in rodent obesity models demonstrated that AOD9604 administration reduced body weight and fat mass without affecting food intake, indicating a direct metabolic effect rather than an appetite-suppressing mechanism

(Seoul, Korea)

We recently identified that ELAM binds directly to key components of the ADP/ATP transport and production pathways including ANT and ATP Synthase as well as 10 other mitochondrial proteins including proteins involved in ATP transport, the electron transport system, and glutamate metabolism [7]

Ultimately, the proper balance between ROS formation and elimination has to be maintained

Although AD-9308 does not activate ALDH1A1, ALDH3A1, ALDH4A1, ALDH5A1 and ALDH7A1 members of the ALDH family, it is possible that AD-9308 may still have non-specific effect on other ALDHs

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