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The synthesis in extrapineal sites presumably does not follow circadian rhythms, except for the retina, and mainly works as a local antioxidant 15,16

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This dual pathway is relevant to cellular aging research because oxidative stress is not a standalone hallmark but a cross-cutting mechanism that accelerates telomere shortening, mitochondrial dysfunction, and the accumulation of senescent cells

Early homocysteine research attempting to identify the relationship between homocysteine and health noted that incremental increases in homocysteine levels were accompanied by a higher risk of cardiovascular disease and death

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the soluble form can also be shed from activated platelets that express membrane bound P-selectin [63]