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Although OA pathogenesis is exceedingly complex, recent studies underscore the multifactorial nature of the disease, involving mechanical overload, inflammatory responses, metabolic abnormalities, and cell death ( Cartilage deterioration and subchondral bone remodeling are hallmarks of OA

Authors' Contributions Soheila Montazersaheb and Raheleh Farahzadi contributed mainly to design and manuscript writing
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10.3389/fncel.2022.827527 Front
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