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This phenomenon was first observed in a 2013 study by Pasquier et al., which demonstrated that endothelial cells preferentially transfer mitochondria to cancer cells via tunneling nanotubes, leading to enhanced chemoresistance by promoting mitochondrial acquisition and survival advantages in recipient tumor cells [466]

Safety Considerations for Chronic Treatment: The chronic nature of autoimmune diseases dictates that ADC therapy may require long-term or intermittent administration, which is in stark contrast to the finite treatment courses in oncology

[DOI] [PubMed] [Google Scholar] Herschbach C., Rennenberg H

Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer

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So the ability to trigger this program indicates the potentially dangerous nature of DMSO