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[Abstract]2023 Apr 20;24(8):7608

After 5 days the total AsA content and APx activity were restored in order to deal with the oxidative challenge but the DHA/AsA ratio remained high, indicating that the oxidative challenge was still active

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Once GSH is exhausted, the sulfhydryl groups of haemoglobin and probably of other proteins are oxidized to disulfides or sulfoxides, resulting in coarse precipitates of denatured haemoglobin, Heinz bodies (see Fig 2B) and the formation of haemichromes, which cause irreversible damage to the membrane: specifically, abnormal proteolytic activity is associated with increased intracellular calcium, as well as binding of haemichromes to band 3 molecules