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The metabolic acidosis and the 5-oxoprolinuria in these patients are explained by the decreased feedback inhibition of -glutamylcysteine ligase resulting from the lower GSH levels

J Natl Cancer Inst 95:17581764

(2017), who observed increased gut permeability (assessed by the FITC-Dextran assay) in 20 week old, but not 4 week old, spontaneously hypertensive rats (SHR) relative to age-matched Wistar Kyoto (WKY) rats [92]

scDCA: deciphering the dominant cell communication assembly of downstream functional events from single-cell RNA-seq data

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These findings indicate that omega-3 and vitamin B12 can counteract several PPA-induced biochemical abnormalities, although the evidence remains limited to an animal model and cannot be directly extrapolated to clinical populations ( The study of Doaei evaluated whether omega-3 supplementation modifies behavioral and social symptoms in children diagnosed with ASD according to DSM IV-TR criteria and ADOS assessment