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The controversial effects of vitamin C on cell culture do not translate into side effects in clinical studies, thus polarizing the research outcome and making it difficult to draw clinical guidelines for vitamin C implementation as a therapeutic medicine

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Reduced mitochondrial calcium uptake in macrophages is a major driver of inflammaging

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We refer the reader to the FY 2021 IPPS/LTCH final rule for a complete discussion of this policy (85 FR 58737 through 58742)

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