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doi: 10.1016/j.beem.2020.101387 5

Vitamin D supplements may interact with other vitamins or drugs, including: Calcium supplements or medications containing calcium Mineral oil Bile acid sequestrants Thiazide diuretics Vitamin D dosage can vary wildly

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Blocking NNMT preserves the NAD+ precursor pool (1.2-1.6x increase in intracellular NAD+), increases SAM availability for epigenetic methylation, and activates SIRT1/SIRT3 signaling

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