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When available, experiments with GluN2C/D non-competitive antagonists should confirm whether results are due to different subunit composition of the receptors at pre- and postsynaptic sites or to different kinetics of glutamate transients at different locations

Conventional therapy is largely about managing the crisis

Nevertheless, because lysine conjugation operates under mild conditions and does not require genetic engineering of the antibody, it remains one of the important strategies for constructing ADCs, especially as site-specific linker technologies are revitalizing the application of lysine in the ADC field

RNA (1 g) was processed and hybridized onto the Human Exon 1.0 ST array (Affymetrix Inc., Santa Clara, CA, USA) according to the manufacturer's protocol as previously described [15]