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Cyclization provides a general strategy for improving peptide proteolytic stability, cell membrane permeability and target binding affinity

Amino Acid Sequence:Gly-His-Lys-Cu (Copper bonded tripeptide)

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The GLS2 structures reveal that the activation loop, a motif previously identified to regulate enzymatic activity, assumes a unique conformation and works together with a lid that closes over the active site to lock in the substrate glutamine