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Hess and Aspascia Cobure, while measuring the intrinsic viscosity of mixed proteins, including blood plasma and serum, observed that pathological samples had a higher intrinsic viscosity than normal ones, reflecting the increase in large, flexible proteins such as fibrinogen, 2 -globulins, and -globulins in the disease states (Hess and Cobure, 1950)
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PMID: 37923932
