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Additional regulatory mechanisms include SRC-2mediated reductive carboxylation, compensatory glutamine addiction induced by PDHA1 loss, Guanine Monophosphate Synthetase(GMPS) driven purine biosynthesis, reciprocal regulation between GLS and CAD, epigenetic modulation via MeCP2/DNMT, and C5a complement signaling that promotes glutamine consumption in castration-resistant prostate cancer (4143)

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Lipid-based nanocarriers such as liposomes or liposome-based, nanostructured lipid carriers (NLCs), and solid lipid nanoparticles (SLNs) have been extensively investigated to improve oral absorption, stability, and bioavailability of quercetin due to their cell membrane-like structures

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