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54: Suppl 4: 113-125

This imbalance between proteases and their physiologic inhibitors favors active proteases to degrade lung structural proteins, particularly elastin, leading to the loss of organ architecture, hence emphysema development [16,17]

Biomed Pharmacother 89:681688 Wang H, Zhu J, Jia Z, Lu S (2022a) Pretreatment of diabetic aged rats with combination of ginsenoside-Mc1 and silibinin protects liver from ischemia-reperfusion injury through an AMPK-dependent mechanism

doi: 10.1038/d41586-019-00669-x

Liao et al

Major modifications for 2025 As outlined in the 2025 Summary of Major Modifications and Explanatory Notes, the major modifications for 2025 include the following: Further examples were added to the following substance classes to help athletes and their entourage better identify prohibited substances: S0