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Deletion of Kir6.2/SUR1 potassium channels rescues diminishing of DA neurons via decreasing iron accumulation in PD

Strain, J

Journal of Ethnopharmacology , 298 , 115544115553

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Triptolide attenuates IL-6-induced activation of STAT3 target genes, such as Mcl-1 and Bcl-2 , by decreasing STAT3 phosphorylation and inhibiting its nuclear translocation in NSCLC (PC9 and A549) cells, while also reversing IL-4 or LPS-induced up-regulation of IL-6 at the gene level, thereby reducing cell survival, apoptosis, and the polarization of myeloid cells into immunosuppressive macrophages and MDSCs within the tumor microenvironment [978, 979]

Reduced levels of SLC7A11 have been observed in fibroblasts associated with IPF, which exhibit a senescent phenotype [209]