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10.1074/jbc.M503062200 21 ChenL.GongQ.SticeJ

Nicotinamide improves aspects of healthspan, but not lifespan, in mice

However, the specific antioxidative metabolites produced by metformin-treated microbiota and their anti-IIRI effects have not been fully elucidated

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Cardiovasc Res 2024: ivabradine, a funny-current (HCN/I_f) blocker, does not abolish the effect, which places the chronotropy on the SR calcium clock rather than the funny channel

Abdulmughni LA, Al-Sanabani JA, Gilan WM, Issa MA, Jowah HM