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doi: 10.1021/ACS.NANOLETT.3C04706 96 AlhakamyNAShadabM

For instance, EGCG significantly inhibits LDH in pancreatic cancer cells, an enzyme that catalyzes the conversion of pyruvate into lactate, and this suppression was observed to be comparable to that of oxamate, an inhibitor of LDH (177, 189)

An increased generation of pro-inflammatory factors within the uterine arteries was also observed, which may have a potentially negative impact on the course of pregnancy (306)

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The demonstration that the oxidative stress associated with mycotoxins can be related to direct suppression of GCLC gene function, post-translational modification of Nrf2 or the presence of excess TGF- suggests that the lack of glutathione may be due to the inability of mycotoxin-affected cells to adequately form glutathione