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Of the 9 referred patients, 3 were treated with oral vitamin B 12 replacement therapy, 2 were given vitamin B 12 injection, and 2 were treated with both oral vitamin B 12 replacement and injection

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RK12V-SP cells showed self-renewal capacity, the potential to develop into stromal cells, reduced expression levels of differentiation markers, long-term proliferating capacity in cultures, and enhanced tumorigenicity, indicating that RK12V-SP cells have cancer stem-like cell features