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With a molecular weight of just 403.93 Da well below the 500 Da cutoff typically associated with significant skin penetration GHK-Cu is small enough to penetrate the stratum corneum (outer skin layer) in concentrations sufficient to activate regenerative processes

doi: 10.3389/fimmu.2022.986847 Received 05 July 2022 Accepted 08 September 2022 Published 23 September 2022 Volume 13 - 2022 Edited by Keiji Hirota, Kyoto University, Japan Reviewed by Michihito Kono, Hokkaido University, Japan

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The prescribing information for Mounjaro does not list vitamin B12 deficiency as a recognised adverse effect, and clinical trials have not identified a direct mechanistic link between the medication and B12 status