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The AT mechanism of all of the above-mentioned compounds usually involves conversion of manganese to an Mn IV -oxo form, which is then reducible by endogenous or exogenous AT (e.g., glutathione or vitamin C) activity (Halliwell and Gutteridge, 2015)

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Zong, L

In addition, studies in human subjects implicate GPx-1 in some cancers and cardiovascular diseases

proposed the use of ROS inducers as therapeutic agents against RNA viruses to induce the degradation of nascent viral RNA within host cells, as RNA is more susceptible to ROS-mediated degradation than DNA or proteins 147

doi: 10.1038/s41418-020-00644-4