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189 , 190 Magnetophoresis has been proposed as a method to increase the accumulation and potential penetration of NMs in tumours

As blood vessels dilate and peripheral resistance drops, the heart may increase rate to maintain blood pressure

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Treatment, reminiscent of the medieval approach to disease, is to remove (phlebotomize) one or even several units of blood (1 unit = 500 mL) from the patient on a regular basis until the iron overload is corrected, as evidenced by normal plasma ferritin levels

Acknowledgments The authors would like to thank all study participants who were enrolled in this study