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Subjective symptoms alone aren't reliable

doi: 10.1093/ajcn/83.5.1177

Neurodegenerative changes in the auditory nerve post-noise exposure trigger neuroplastic alterations within the cochlear nucleus, reshaping synaptic structure and function

Specifically, CHAC1 provides neuroprotection during damage induced by subarachnoid or intracerebral hemorrhage ( CHAC1/BOTCH , which significantly reduced neuroinflammation by blocking NOTCH1 signaling ( The regulation of CHAC1/BOTCH involves additional molecular players: during intracerebral hemorrhage, inhibition of CHAC1/BOTCH by the androgen receptor (AR) and Jumonji-domain containing protein-3 (JMJD3) led to elevated NOTCH1 levels and exacerbated neuroinflammation ( ATF4 was most prominently upregulated, though other related genes were also significantly elevated (Yasuda et al., 2014)

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Yamamoto et al., 2011), although there have been no human clinical trials