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25(OH)D is biologically inactive and must be converted to its active form, 1,25(OH)2D3, by 1-hydroxylase in the kidneys (82)

2 These improvements in MS care have led to a significant epidemiological shift, with the highest prevalence in people aged 30 to 40 years in the 1980s to those aged 55 to 64 years in the 2010s

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