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The parietal cells of the stomach secrete a glycoprotein called intrinsic factor, which takes B12 from the R-factor and carries it to the last part of your intestine, called the ileum, for absorption of B12

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Because B12 is found primarily in animal products, plant-based diets can increase the risk of deficiency

PLOS Computational Biology 18 (7): e1010330.

Intrinsic factor replacement therapy is typically recommended for individuals who have Type 1 pernicious anemia and have an autoimmune disorder that affects the stomach's ability to produce intrinsic factors