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Enzymatic pathways naturally exist in nature that can degrade nicotine into non-toxic compounds

In mice, FGF21 appears to improve glycemic control and lipid homeostasis via centrally-mediated pathways (287, 288)

Endoplasmic reticulum membranes are enriched with polyunsaturated fatty acid-containing phospholipids (PUFA-PLs), highlighting the pleiotropic nature of lipids which function as cell death mediators, signaling molecules, and metabolic substratesa functional diversity underpinned by the lipidomes immense structural variation across tissues, cell types, and organelles (111)

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conversely, blocking HMGB1 release or counteracting its function alleviates inflammation and fibrosis [251, 278]

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