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The transport of drug molecules from the nasal cavity to the brain involves two primary pathways: intracellular and extracellular

After rats were injected with a standardized extract of ginkgo biloba, catalase and superoxide dismutase activities in the hippocampus, striatum, and substantia nigra were increased, lipid peroxidation decreased, and overall oxidative damage was reduced (Plascencia-Villa and Perry, 2021)

During the test, the mice were placed on Rotarod test device (BYZ-007, China) and started to rotate from 5 revolutions per minute (rpm), and increased to the maximum speed of 40 rpm within 150 s, for a total of 5 min

In contrast, LUHMES cells express a substantial amount of synuclein during differentiation into post-mitotic DA neurons by use of tetracycline (to switch-off the tetracycline-responsible myc gene), cyclic AMP, and GDNF (Lotharius et al., 2016)

Paclitaxel was not included in the set of 68 drugs evaluated in the Sharlow et al

J., Lan F., Matson C., Mulligan P., Whetstine J