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5 The majority of the Indian population is at high risk of developing nutritional vitamin B12 deficiency, due to strict vegetarian food habits

In this paper, we consider as outcomes of interest the [GSH]/[GSSG] ratio and the model outputs for the concentration of NADPH, ROS and G6P at time points for which calibration and validation data measurements are available (PN12, PN13, PN15, PN17, PN28)

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Current oral formulations of donepezil, the primary acetylcholinesterase inhibitor for AD treatment, suffer from significant limitations, including the requirement for high systemic doses to achieve therapeutic brain concentrations, extensive first-pass hepatic metabolism, and dose-limiting peripheral side effects such as nausea, vomiting, and gastrointestinal bleeding that compromise patient compliance and quality of life 4

MANF promotes the malignant biological behaviors of ICC cell lines in vitro and in vivo The above data suggest an oncogenic role of MANF in ICC

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