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Description
Insulin binds to receptors in the brain and primarily modulates two signaling cascades, including the phosphoinositide 3-kinase (PI3K) pathway controlling metabolism and the mitogen-activated protein kinase pathway, regulating mitochondrial function, proliferation, and growth (Kullmann et al

doi: 10.3390/ijms241511976

Fan, M., Zhang, J., Lee, C
doi:10.1046/j.1523-1747.2000.00166.x

Am J Med Genet 2002;107(2):1515

Unlike its derivates, such as nicotinic acid, nicotinamide riboside, and nicotinamide mononucleotide, which may cause side effects like flushing, itching, hypotension, and headaches, NAM is generally safe and well-tolerated, even at high doses (up 3 mg/die), with rare adverse effects observed over prolonged treatments [10,11,12]
