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Further, carnitine binds acyl residues resulting from the intermediary metabolism of amino acids (branched-chain especially) to aid their elimination, and it regulates the acyl-CoA/CoA ratio, thereby controlling the activity of several mitochondrial enzymes

Even though the 3D structure of OCTN2 is still not known, the molecular determinants for substrate specificity have been revealed: one ammonium and one carboxylate groups are strictly required for transport, while the distance between them is not important (Ohashi et al., 2002

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